Swansea University, Swansea, Wales, U.K.
RMA DelaysOur Admin Portal website is currently experiencing technical difficulties, and it could result in delays with RMAs being processed. We are currently working to resolve these issues. We apologize for the inconvenience.
Join us on August 11th for an ActiGraph webinar hosted by Xtalks:
Oncology Research and Care: Reimagining Digital InnovationRegister Now
Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study
- Published on Feb. 20, 2019
Objective: The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.
Research Design and Methods: Participants (n = 2,326; 25–70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m−2 and impaired fasting glucose (5.6–6.9 mmol ⋅ L−1) or impaired glucose tolerance (7.8–11.0 mmol ⋅ L−1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.
Results: Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = −0.078 [95% CI −0.128, −0.027]), waist circumference (WC) (β = −0.177 [−0.122, −0.134]), fasting insulin (β = −0.115 [−0.158, −0.072]), 2-h glucose (β = −0.069 [−0.112, −0.025]), triglycerides (β = −0.091 [−0.138, −0.044]), and CRP (β = −0.086 [−0.127, −0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, −0.172]). Associations reported between total PA (counts ⋅ min−1), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = −0.151 [−0.194, −0.107]), WC (β = −0.179 [−0.224, −0.134]), fasting insulin (β = −0.139 [−0.183, −0.096]), 2-h glucose (β = −0.088 [−0.131, −0.045]), triglycerides (β = −0.117 [−0.162, −0.071]), and CRP (β = −0.104 [−0.146, −0.062]).
Conclusions: In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.
- Nils Swindell 1
- Kelly Mackintosh 1
- Melitta McNarry 1
- Jeffrey W. Stephens 1
- Diewertje Sluik 2
- Mikael Fogelholm 3
- Mathijs Drummen 4
- Ian MacDonald 5
- J. Alfredo Martinez 6
- Teodora Handjieva-Darlenska 7
- Sally D. Poppitt 8
- Jennie Brand-Miller 9
- Thomas M. Larsen 10
- Anne Raben 10
- Gareth Stratton 1
Division of Human Nutrition, Wageningen University & Research, Wageningen, the Netherlands
University of Helsinki, Helsinki, Finland
Maastricht University, Maastricht, the Netherlands
University of Nottingham, Nottingham, U.K.
University of Navarra, Pamplona, Spain, and CIBERObn and IMDEA, Instituto de Salud Carlos III, Madrid, Spain
Medical University of Sofia, Sofia, Bulgaria
University of Auckland, Auckland, New Zealand
University of Sydney, Sydney, Australia
University of Copenhagen, Copenhagen, Denmark