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Physical activity in pediatric pulmonary arterial hypertension measured by accelerometry: A candidate clinical endpoint
Background: Although the six-minute walk distance is well established as a clinically relevant endpoint for adults with pulmonary arterial hypertension (PAH), this endpoint is less applicable to infants and children who may be unable to participate in such testing. Thus, there is a critical need to develop and validate means of assessing activity levels in younger populations that can be applied to clinical trial design. Accelerometry has previously been used in adults and children to measure physical activity, but whether accelerometry correlates with disease severity and outcomes in pediatric PAH remains unknown.