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Category: Cardiovascular Disease Featured National Health and Nutrition Examination Survey (NHANES) Obesity
Back to Research DatabaseSedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06
| Author(s) | Genevieve N. Healy1,2, Charles E. Matthews3, David W. Dunstan1,2, Elisabeth A.H. Winkler1 and Neville Owen1,2 |
| Institution(s) | 1 - Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Herston Rd, Herston, QLD 4006, Australia 2 - Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Victoria 8008, Melbourne, Australia 3 - Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892-7335, USA |
| Journal | European Heart Journal Published: 01/13/2011 |
| Presented at: | -- |
| Download PDF | N/A |
Abstract
Aims: Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity.
Methods and results: Cross-sectional analyses with 4757 participants (?20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [<100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends <0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-%B, and HOMA-%S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends <0.05). There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks.
Conclusion: These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.
Full article: http://eurheartj.oxfordjournals.org/content/early/2011/01/08/eurheartj.ehq451.full
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